Virucidal and chlamydicidal activities of eye drops with povidone-iodine liposome complex.

Abstract

Povidone-iodine (PVP-I) is a broad-spectrum microbicide with in vitro activity against bacteria, viruses, fungi and protozoans. A 5% solution of PVP-I proved to be highly effective in ophthalmic surgery for the prophylaxis of endophthalmitis. For the antiseptic treatment of eye infections a novel application form of PVP-I has been developed by using a PVP-I liposome complex which demonstrated an excellent antimicrobial efficacy. In this study it could be shown that the novel liposomal formulations containing 2.5 or 5% PVP-I were as active as the aqueous solution against herpes simplex virus type 1, adenovirus type 8, coxsackievirus A9 and Chlamydia trachomatis in cell culture referring to equal PVP-I concentrations. Long-term cytotoxicity experiments demonstrated a moderate cytotoxicity for both formulations with a better tolerability of the liposomal PVP-I formulation compared with the aqueous solution. There is no evidence for a genotoxic activity of these agents.

• Authors: P Wutzler, A Sauerbrei, R Klöcking, J Burkhardt, M Schacke, R Thust, W Fleischer, K Reimer
• Journal: Ophthalmic research (Ophthalmic Res) 2000 Mar-Jun Vol. 32 Issue 2-3 Pg. 118-25 ISSN: 0030-3747 [Print] Switzerland
• PMID: 10754445 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright 2000 S. Karger AG, Basel

Chemical References

• Anti-Infective Agents, Local
• Liposomes
• Ophthalmic Solutions
• Povidone-Iodine

Topics

• Adenoviruses, Human (drug effects)
• Animals
• Anti-Infective Agents, Local (pharmacology)
• Chlamydia trachomatis (drug effects)
• Chlorocebus aethiops
• Dose-Response Relationship, Drug
• Enterovirus (drug effects)
• Herpesvirus 1, Human (drug effects)
• Humans
• Liposomes
• Male
• Ophthalmic Solutions (pharmacology)
• Povidone-Iodine (pharmacology)
• Rabbits
• Vero Cells