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DNA double strand break repair in mammalian cells.

Abstract
Human cells can process DNA double-strand breaks (DSBs) by either homology directed or non-homologous repair pathways. Defects in components of DSB repair pathways are associated with a predisposition to cancer. The products of the BRCA1 and BRCA2 genes, which normally confer protection against breast cancer, are involved in homology-directed DSB repair. Defects in another homology-directed pathway, single-strand annealing, are associated with genome instability and cancer predisposition in the Nijmegen breakage syndrome and a radiation-sensitive ataxia-telangiectasia-like syndrome. Many DSB repair proteins also participate in the signaling pathways which underlie the cell's response to DSBs.
AuthorsP Karran
JournalCurrent opinion in genetics & development (Curr Opin Genet Dev) Vol. 10 Issue 2 Pg. 144-50 (Apr 2000) ISSN: 0959-437X [Print] England
PMID10753787 (Publication Type: Journal Article, Review)
Chemical References
  • DNA
Topics
  • Animals
  • Cell Nucleus (genetics)
  • Cell Transformation, Neoplastic (genetics)
  • DNA (genetics)
  • DNA Damage (genetics)
  • DNA Repair (genetics)
  • Humans
  • Recombination, Genetic

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