Abstract |
Human cells can process DNA double-strand breaks (DSBs) by either homology directed or non-homologous repair pathways. Defects in components of DSB repair pathways are associated with a predisposition to cancer. The products of the BRCA1 and BRCA2 genes, which normally confer protection against breast cancer, are involved in homology-directed DSB repair. Defects in another homology-directed pathway, single-strand annealing, are associated with genome instability and cancer predisposition in the Nijmegen breakage syndrome and a radiation-sensitive ataxia-telangiectasia-like syndrome. Many DSB repair proteins also participate in the signaling pathways which underlie the cell's response to DSBs.
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Authors | P Karran |
Journal | Current opinion in genetics & development
(Curr Opin Genet Dev)
Vol. 10
Issue 2
Pg. 144-50
(Apr 2000)
ISSN: 0959-437X [Print] England |
PMID | 10753787
(Publication Type: Journal Article, Review)
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Chemical References |
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Topics |
- Animals
- Cell Nucleus
(genetics)
- Cell Transformation, Neoplastic
(genetics)
- DNA
(genetics)
- DNA Damage
(genetics)
- DNA Repair
(genetics)
- Humans
- Recombination, Genetic
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