| Abstract | We report a 21-year-old male with childhood-onset familial nephrotic syndrome and frequent relapses who manifested toxicity or treatment resistance to corticosteroids, cyclophosphamide, cyclosporin-A, and tacrolimus. Monotherapy with mycophenolate mofetil (MMF) resulted in maintenance of clinical remission for 14 months without noticeable toxicity, while allowing resolution of steroid-induced side effects. Our observation suggests that MMF may be useful in maintaining remission in nephrotic patients who manifest toxicity to standard immunosuppressive agents. |
| Authors | M Chandra, M Susin, C Abitbol
(Affiliation: Department of Pediatrics, North Shore University Hospital, New York University School of Medicine, Manhasset 11030, USA.)
|
| Journal | Pediatric nephrology (Berlin, Germany)
(Pediatr Nephrol)
Vol. 14
Issue 3
Pg. 224-6
(Mar 2000)
ISSN: 0931-041X GERMANY |
| PMID | 10752763
(Publication Type: Case Reports, Journal Article)
|
| Chemical References |
- Immunosuppressive Agents
- mycophenolate mofetil
- Mycophenolic Acid
|
| Topics |
- Child, Preschool
- Drug Resistance
- Humans
- Immunosuppressive Agents
(adverse effects, therapeutic use)
- Male
- Mycophenolic Acid
(analogs & derivatives, therapeutic use)
- Nephrotic Syndrome
(drug therapy)
- Recurrence
- Remission Induction
- Retreatment
|
