Abstract |
Recurrence of IgA nephropathy (IgAN) following renal transplantation has been described in 40-50% of such patients and it usually has a good outcome. We present the case of a 20-yr-old woman with IgAN who developed end-stage renal failure in 1995. In November 1996, she received a kidney from a living-related donor and was treated with tacrolimus, azathioprine and steroids. Zero- and one-hour biopsies were performed, which revealed minor glomerular abnormalities in light microscopy, thin basement membrane disease (TBMD) in electron microscopy. Eight months later she developed microscopic hematuria and proteinuria; however, the graft function was normal. Renal biopsy revealed an IgAN that is thought to be due to recurrence of the original disease.
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Authors | Y Nakagawa, K Saito, S Nishi, V Bilim, T Tanikawa, M Ueno, H Shimada, Y Osawa, M Arakawa, K Takahashi |
Journal | Clinical transplantation
(Clin Transplant)
Vol. 13 Suppl 1
Pg. 59-62
( 1999)
ISSN: 0902-0063 [Print] Denmark |
PMID | 10751059
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Adult
- Basement Membrane
(ultrastructure)
- Biopsy
- Female
- Glomerulonephritis, IGA
(pathology, surgery)
- Humans
- Immunosuppressive Agents
(therapeutic use)
- Kidney Glomerulus
(pathology)
- Kidney Transplantation
(pathology)
- Living Donors
- Microscopy, Electron
- Recurrence
- Time Factors
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