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A randomized, comparative study of fluorometholone 0.2% and fluorometholone 0.1% acetate after photorefractive keratectomy.

AbstractPURPOSE:
To compare the efficacy and tolerance of fluorometholone 0.1% acetate and fluorometholone 0.2% eyedrops in the postoperative management of photorefractive keratectomy (PRK).
METHODS:
A randomised single-blind comparative study was performed on two groups of 30 patients who underwent myopic PRK. The first group was given fluorometholone 0.1% acetate and the second fluorometholone 0.2%. Uncorrected and best corrected visual acuity, haze, IOP and local tolerance were evaluated. Statistical analysis was done using parametric and non-parametric tests.
RESULTS:
Visual acuity did not differ in the two groups; both were homogeneous as far as refractive error and haze were concerned. Three patients (10%) treated with fluorometholone 0.2% and two patients (6.6%) with fluorometholone 0.1% acetate developed ocular hypertension, but this was not statistically significant.
CONCLUSIONS:
Fluorometholone 0.1% acetate was effective on inflammation after PRK, with the same efficacy as fluorometholone 0.2%.
AuthorsM Vetrugno, G M Quaranta, A Maino, L Cardia
JournalEuropean journal of ophthalmology (Eur J Ophthalmol) 2000 Jan-Mar Vol. 10 Issue 1 Pg. 39-45 ISSN: 1120-6721 [Print] United States
PMID10744204 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Anti-Inflammatory Agents
  • Glucocorticoids
  • Ophthalmic Solutions
  • Fluorometholone
Topics
  • Administration, Topical
  • Adult
  • Anti-Inflammatory Agents (administration & dosage, adverse effects, therapeutic use)
  • Female
  • Fluorometholone (administration & dosage, adverse effects, therapeutic use)
  • Glare
  • Glucocorticoids
  • Humans
  • Intraocular Pressure (drug effects)
  • Lasers, Excimer
  • Male
  • Myopia (surgery)
  • Ophthalmic Solutions (administration & dosage, adverse effects, therapeutic use)
  • Photorefractive Keratectomy (adverse effects)
  • Safety
  • Single-Blind Method
  • Uveitis, Anterior (etiology, prevention & control)
  • Visual Acuity (drug effects)

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