Improved postprandial glycemic control with Humalog Mix75/25 after a standard test meal in patients with type 2 diabetes mellitus.

Abstract

OBJECTIVE:

This double-blind study was designed to compare the postprandial glucodynamic profile of Humalog Mix75/25, a new premixed insulin analogue containing 75% neutral protamine lispro and 25% insulin lispro with that of human insulin 70/30 (70% neutral protamine Hagedorn insulin and 30% regular human insulin) in patients with type 2 diabetes mellitus.

BACKGROUND:

Insulin lispro Mix75/25 (Mix75/25) is the first available insulin formulation in which both the rapid-acting and basal components are insulin analogues.

METHODS:

This randomized, multicenter, double-blind, crossover study monitored patients' postprandial glucodynamic response to Mix75/25 and human insulin 70/30 (70/30) after a standard test meal. Eighty-four patients with type 2 diabetes participated in this study and were randomly assigned to 1 of 2 treatment sequence groups. Patients received an identical test meal on 4 occasions, completing 2 test meals for each treatment. Equal doses of Mix75/25 or 70/30 were administered 5 minutes before each of the 2 test meals, with doses individualized for each patient. Blood samples were collected for 4 hours after the meal for measurement of plasma glucose. From these plasma glucose measurements, fasting plasma glucose, 2-hour postprandial glucose (2pp), 2-hour postprandial glucose excursion (2pp(ex)), maximum glucose excursion (Gex(max)), the area under the glucose concentration versus time curve from 0 to 4 hours (AUC4), and the area under the glucose excursion versus time curve from 0 to 4 hours (AUCex4) were calculated.

RESULTS:

Because of significant differences in the baseline fasting plasma glucose levels between Mix75/25 and 70/30 (Mix75/25: 8.9+/-2.2 mmol/L [160.2+/-39.6 mg/dL]; 70/30: 8.6+/-1.9 mmol/L [154+/-34 mg/dL), analyses of the excursion parameters provide a truer comparison of the glucodynamic response between insulin formulations. Mix75/25 resulted in significantly lower values for 2pp(ex) (3.35+/-2.28 vs 4.13+/-2.26 mmol/L), Gex(max) (4.51+/-1.88 vs 5.19+/-1.98 mmol/L), and AUCex4 (8.01+/-7.02 vs 10.6+/-6.47 mmol x h/L) compared with 70/30.

CONCLUSIONS:

In patients with type 2 diabetes mellitus, premeal injection of Mix75/25 resulted in better postprandial glycemic control than did premeal injection of 70/30 in the 4 hours after a standard meal. Mix75/25 is a valuable option for managing postprandial blood glucose in patients with type 2 diabetes mellitus who require insulin.

• Authors: J K Malone, J R Woodworth, V Arora, H Yang, B N Campaigne, J P Hallé, J F Yale, L D Grossman
• Journal: Clinical therapeutics (Clin Ther) Vol. 22 Issue 2 Pg. 222-30 (Feb 2000) ISSN: 0149-2918 [Print] United States
• PMID: 10743981 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Blood Glucose
• Hypoglycemic Agents
• Insulin
• Insulin Lispro
• Protamines
• neutral protamine lispro insulin

Topics

• Adult
• Aged
• Area Under Curve
• Blood Glucose (drug effects)
• Cross-Sectional Studies
• Diabetes Mellitus, Type 2 (drug therapy)
• Double-Blind Method
• Female
• Humans
• Hypoglycemic Agents (administration & dosage, pharmacokinetics, therapeutic use)
• Injections, Intravenous
• Insulin (administration & dosage, analogs & derivatives, pharmacokinetics, therapeutic use)
• Insulin Lispro
• Male
• Middle Aged
• Postprandial Period
• Protamines (administration & dosage, pharmacokinetics, therapeutic use)