Abstract |
It has been suggested that milk fat, due to its content of saturated fatty acids, may have a thrombogenic effect. In the present study the fatty acid profile of milk fat was modified by changing the feeding regimens of cows and the effect on haemostatic variables of a diet containing the modified milk fat (M) was compared with that of a diet containing milk fat of typical Danish composition (D). In the modified fat 16% of the saturated fatty acid (C12-C16) content was replaced mainly by oleic acid. Eighteen subjects were fed on two strictly controlled isoenergetic diets containing 40% energy from total fat (30% energy from the test fats) for periods of 4 weeks in a study with a crossover design. Fasting samples were taken in the last week of each study period. Postprandial samples were taken on day 21, 3 h after lunch (n 18), and on the last day of the study 2, 4, 6 and 8 h after a fat load containing 1.2 g of one of the milk fats/kg body weight (n 8). After 4 weeks' dietary intervention fasting plasma factor VII coagulant (FVIIc) activity, tissue-type plasminogen activator (t-PA) activity, plasminogen activator inhibitor (PAI-1) antigen and beta-thromboglobulin did not differ between diets M and D. Postprandially FVIIc and t-PA activities increased (P < 0.001) and PAI-1 antigen and PAI-1 activity decreased (P < 0.001) as compared with fasting values, regardless of diet. After the fat load, the postprandial increase in FVIIc was marginally lower after diet M than diet D (diet effect, P < 0.05). In conclusion, the modified milk fat obtained by the applied feeding strategy had virtually the same effects on haemostatic variables as conventional milk fat.
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Authors | T Tholstrup, P Marckmann, J Hermansen, G Hølmer, B Sandström |
Journal | The British journal of nutrition
(Br J Nutr)
Vol. 82
Issue 2
Pg. 105-13
(Aug 1999)
ISSN: 0007-1145 [Print] England |
PMID | 10743482
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Fatty Acids
- Plasminogen Activator Inhibitor 1
- Triglycerides
- beta-Thromboglobulin
- Factor VII
- Tissue Plasminogen Activator
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Topics |
- Adult
- Animal Nutritional Physiological Phenomena
- Animals
- Cattle
- Cross-Over Studies
- Factor VII
(analysis)
- Fasting
(blood)
- Fatty Acids
(analysis)
- Food, Formulated
- Hemostasis
- Humans
- Male
- Milk
(chemistry)
- Plasminogen Activator Inhibitor 1
(blood)
- Postprandial Period
- Tissue Plasminogen Activator
(blood)
- Triglycerides
(blood)
- beta-Thromboglobulin
(analysis)
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