[Therapy of primary open-angle glaucoma by oftan-dipivefrin].

Abstract	Choice of optimal hypotensive therapy with the minimal side effects remains a serious problem in therapy of glaucoma. The efficacy and safety of oftan-dipivefrin (Sante, Finland) and glaucon (Alcon, USA) are compared in a controlled balanced randomized open parallel study preceded by a period for discharge of the previous drugs. The period of discharge was 7 days, active treatment was administered for 8 weeks. Sixty patients aged 61-69 years were treated. Thirty-one patients were treated by oftan-dipivefrin (group 1) and 29 by glaucon (group 2). In parallel with this, a 1% pilocarpin solution was administered in both groups. The examinations carried out during all consultations included measurements of intraocular pressure before instillations every day at the same time, evaluation of visual acuity, tonography, and study of the central and peripheral visual fields. The time course of hypotensive effects of both drugs showed a sufficient decrease in intraocular pressure in both groups; the effect of oftan-dipivefrin was more pronounced, while glaucon caused the least number of side effects.
Authors	E A Egorov, V N Alekseev, V P Erichev, V V Usachev, S V Simonova, L V Iakubova
Journal	Vestnik oftalmologii (Vestn Oftalmol) 2000 Jan-Feb Vol. 116 Issue 1 Pg. 32-3 ISSN: 0042-465X [Print] Russia (Federation)
Vernacular Title	Preparat "Oftan-dipivefrin" v lechenii pervichnoĭ otkrytougol'noĭ glaukomy.
PMID	10741262 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)
Chemical References	Adrenergic Agonists Miotics Ophthalmic Solutions Pilocarpine dipivefrin Epinephrine
Topics	Adrenergic Agonists (administration & dosage, therapeutic use) Aged Drug Therapy, Combination Epinephrine (administration & dosage, analogs & derivatives, therapeutic use) Female Glaucoma, Open-Angle (drug therapy) Humans Intraocular Pressure (drug effects) Male Middle Aged Miotics (administration & dosage, therapeutic use) Ophthalmic Solutions Pilocarpine (administration & dosage, therapeutic use) Safety Treatment Outcome Visual Acuity Visual Fields

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