Analgesic action of i.v. morphine-6-glucuronide in healthy volunteers.

Abstract

The pharmacodynamics of morphine-6-glucuronide (M-6-G) i.v. were assessed in 12 healthy male volunteers in an open study. After a single bolus dose of M-6-G 5 mg i.v., we measured antinociceptive effects, using electrical and cold pain tests, and plasma concentrations of M-6-G, morphine-3-glucuronide (M-3-G) and morphine. Pain intensities during electrical stimulation (at 30, 60 and 90 min after injection) and ice water immersion (at 60 min) decreased significantly (P < 0.005) compared with baseline. Mean plasma peak concentrations of M-6-G were 139.3 (SD 38.9) ng ml-1, measured at 15 min. Our data demonstrate that M-6-G has significant analgesic activity.

• Authors: T M Buetler, O H Wilder-Smith, C H Wilder-Smith, S Aebi, T Cerny, R Brenneisen
• Journal: British journal of anaesthesia (Br J Anaesth) Vol. 84 Issue 1 Pg. 97-9 (Jan 2000) ISSN: 0007-0912 [Print] England
• PMID: 10740556 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Analgesics, Opioid
• Morphine Derivatives
• morphine-6-glucuronide

Topics

• Adult
• Analgesics, Opioid (blood, therapeutic use)
• Cold Temperature
• Electric Stimulation
• Humans
• Injections, Intravenous
• Male
• Middle Aged
• Morphine Derivatives (blood, therapeutic use)
• Pain Measurement
• Pain, Postoperative (prevention & control)