3-Nitropropionic acid preconditioning ameliorates delayed neurological deterioration and infarction after transient focal cerebral ischemia in gerbils.

Abstract

The effect of 3-nitropropionic acid (3-NP), a selective inhibitor of succinic dehydrogenase, preconditioning on postischemic neurological deterioration and infarction was examined in gerbils after transient ischemia. The animals were pretreated with 1-80mg/kg of 3-NP 1 day before ischemia induced by two 10-min occlusions of the left common carotid artery. Four milligrams per kilogram 3-NP pretreatment significantly ameliorated postischemic neurological deterioration (stroke index at 7 days postischemia, 1.4+/-1.5 vs. 7.4+/-5.4 in 4 mg/kg-pretreated vs. non-pretreated animals: mean+/-SD) and reduced infarct volume (24+/-4.8 vs. 43+/-12 mm(3)). One and 20 mg/kg 3-NP induced milder neuroprotection, and 80 mg/kg 3-NP aggravated postischemic stroke symptoms and infarction. Thus, appropriate doze of 3-NP preconditioning is effective in ameliorating the postischemic neurological deterioration and reducing infarct volume.

• Authors: T Kuroiwa, I Yamada, S Endo, Y Hakamata, U Ito
• Journal: Neuroscience letters (Neurosci Lett) Vol. 283 Issue 2 Pg. 145-8 (Apr 07 2000) ISSN: 0304-3940 [Print] Ireland
• PMID: 10739896 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antihypertensive Agents
• Nitro Compounds
• Propionates
• 3-nitropropionic acid

Topics

• Animals
• Antihypertensive Agents (pharmacology)
• Brain (drug effects, pathology)
• Carotid Artery, Common
• Cerebral Infarction (prevention & control)
• Dose-Response Relationship, Drug
• Gerbillinae
• Ischemic Attack, Transient (drug therapy, pathology, physiopathology)
• Ischemic Preconditioning
• Neurons (drug effects, pathology)
• Nitro Compounds
• Propionates (pharmacology)