Hemopexin as a carrier protein of tumor-localizing Ga-metalloporphyrin-ATN-2.

Abstract

During size exclusion HPLC, ATN-2 binding protein separated from human and mouse sera, SCCVII and colon 26 tumor tissues were found in fraction 13 (A: estimated molecular weight 70,000). Fraction 13(A) of human sera was exclusively reactive to the human hemopexin antibody. During two-dimensional electrophoresis and amino acid sequence analysis, Fraction 13(A) of C3H/He mouse sera was found to have partial homology with the mouse hemopexin precursor. Glycoprotein with the same domain structure of hemopexin has been proposed to be an important carrier protein that forms the tumor-localizing activity of water-soluble porphyrin.

• Authors: S Nakajima, T Moriyama, H Hayashi, I Sakata, Y Nakae, T Takemura
• Journal: Cancer letters (Cancer Lett) Vol. 149 Issue 1-2 Pg. 221-6 (Feb 28 2000) ISSN: 0304-3835 [Print] Ireland
• PMID: 10737728 (Publication Type: Journal Article)

Chemical References

• Carrier Proteins
• Porphyrins
• Hemopexin

Topics

• Animals
• Carrier Proteins (metabolism)
• Colonic Neoplasms (metabolism)
• Electrophoresis, Gel, Two-Dimensional
• Hemopexin (analysis, metabolism)
• Humans
• Mice
• Porphyrins (analysis, metabolism)