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Tumor-targeted chemotherapy with SMANCS in lipiodol for renal cell carcinoma: longer survival with larger size tumors.

AbstractOBJECTIVES:
To evaluate the anticancer effects of a lipophilic macromolecular anticancer agent, poly(styrene-co-maleic acid)-conjugated neocarzinostatin (SMANCS), dissolved in a lipid contrast medium (Lipiodol) given via the renal artery to patients with renal cell carcinoma.
METHODS:
Among 467 patients with renal cell carcinoma treated between April 1984 and March 1993, 191 were treated with SMANCS dissolved in a lipid contrast medium (a 3:2 mixture of Lipiodol F and Lipiodol Ultrafluid; Lpd). Selective arterial infusion of SMANCS/Lpd was performed at a dose of 1.0 or 1. 5 mg/mL. The infusion was repeated at intervals of about 2 weeks or longer, but the doses and the total number of infusions varied among patients, according to results of computed tomography analysis.
RESULTS:
Statistical analysis was performed for 415 patients who met the criteria of this study. Twenty-six surgical patients with metastases who underwent infusion therapy of SMANCS/Lpd for primary lesions showed 3 and 5-year survival rates of 23.0% and 12.8%, respectively; the rates were 19.3% and 9.7% in 31 patients who did not receive SMANCS infusion therapy. In 125 surgical patients without metastases who underwent SMANCS/Lpd infusion, the 5 and 10-year survival rates were 83.0% and 75.2%, respectively, whereas rates of 84.6% and 78.9% were observed in 199 surgical patients whose median tumor size was significantly smaller, however, than the SMANCS/Lpd infusion group. The maximal tumor diameter at the beginning of treatment was significantly larger (mean diameter 70.8 mm) in the SMANCS/Lpd infusion group than in the noninfusion group (59.1 mm). The survival rate was statistically better for patients with tumors of 100 mm diameter or larger in the SMANCS/Lpd infusion group (P <0.05): 5 and 10-year survival rates were 70.4% and 61.6%, respectively, for the infusion group and 64.6% and 50.9% for the group receiving no drug. In patients with larger tumor (greater than 110 mm), the survival rate at 13 years was 75% in the SMANCS/Lpd infusion group and 0% in the surgery group.
CONCLUSIONS:
Arterial infusion therapy with SMANCS/Lpd appears to be effective for large renal cell carcinoma without metastases in conjunction with surgery.
AuthorsK Tsuchiya, T Uchida, M Kobayashi, H Maeda, T Konno, H Yamanaka
JournalUrology (Urology) Vol. 55 Issue 4 Pg. 495-500 (Apr 2000) ISSN: 1527-9995 [Electronic] United States
PMID10736490 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents
  • Maleic Anhydrides
  • Polystyrenes
  • poly(maleic acid-styrene)neocarzinostatin
  • Iodized Oil
  • Zinostatin
Topics
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antineoplastic Agents (administration & dosage, adverse effects)
  • Carcinoma, Renal Cell (drug therapy, mortality, pathology, surgery)
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Female
  • Humans
  • Infusions, Intra-Arterial
  • Iodized Oil (administration & dosage, adverse effects)
  • Kidney Neoplasms (drug therapy, mortality, pathology, surgery)
  • Male
  • Maleic Anhydrides (administration & dosage, adverse effects)
  • Middle Aged
  • Neoadjuvant Therapy
  • Neoplasm Staging
  • Polystyrenes (administration & dosage, adverse effects)
  • Survival Rate
  • Tomography, X-Ray Computed
  • Treatment Outcome
  • Zinostatin (administration & dosage, adverse effects, analogs & derivatives)

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