Transient nonketotic hyperglycinemia in an asphyxiated patient with pyridoxine-dependent seizures.

Abstract

An asphyxiated neonate with pyridoxine-dependent seizures and associated transient nonketotic hyperglycinemia is reported. Frequent seizures and their resultant hypoxic-ischemic insult may have led to the elevation of the cerebrospinal fluid glycine level in this patient. Early diagnosis and treatment of pyridoxine-dependent seizures is essential for an improved neurologic outcome.

• Authors: T Maeda, M Inutsuka, K Goto, T Izumi
• Journal: Pediatric neurology (Pediatr Neurol) Vol. 22 Issue 3 Pg. 225-7 (Mar 2000) ISSN: 0887-8994 [Print] United States
• PMID: 10734255 (Publication Type: Case Reports, Journal Article)

Chemical References

• Pyridoxal Phosphate
• Glycine

Topics

• Asphyxia Neonatorum (complications, metabolism)
• Brain (metabolism)
• Electroencephalography
• Glycine (metabolism)
• Humans
• Hyperglycinemia, Nonketotic (etiology, metabolism)
• Infant, Newborn
• Male
• Pyridoxal Phosphate (therapeutic use)
• Seizures (etiology, physiopathology)
• Treatment Outcome
• Vitamin B 6 Deficiency (complications, drug therapy)