Effects of dietary supplementation with n-3 fatty acids compared with n-6 fatty acids on bronchial asthma.

Abstract

OBJECTIVE:

The effects of perilla seed oil (n-3 fatty acids) on bronchial asthma were compared with the effects of corn oil (n-6 fatty acids) in relation to the pulmonary function and the generation of leukotriene B4 (LTB4) and C4 (LTC4) by leucocytes.

METHODS AND SUBJECTS:

14 asthmatic subjects were divided randomly into two groups: one group (7 subjects) consumed perilla seed oil-rich supplementation and the other group (7 subjects) consumed corn oil-rich supplementation for 4 weeks. Generation of LTs by leucocytes and respiratory function were compared between the two groups.

RESULTS:

The generation of LTB4 and LTC4 by leucocytes tended to increase in subjects (N=7) with corn oil-rich supplementation, and decrease in subjects (N=7) with perilla seed oil-rich supplementation. Significant differences between the two groups were observed in the generation of LTB4 at 2 weeks (p<0.05) and LTC4 at 2 weeks (p<0.05) after dietary supplementation. Significant increases in the value of PEF (p<0.05), FVC (p<0.01), FEV(1.0) (p<0.05) and V(25) (p<0.05) were found in subjects who received perilla seed oil supplementation for 4 weeks. And significant differences in the value of FVC (p<0.05) and FEV(1.0) (p<0.05) were observed between the two groups after 4 weeks of dietary supplementation.

CONCLUSION:

These results suggest that perilla seed oil-rich supplementation is useful for the treatment of asthma in terms of suppression of LTB4 and LTC4 generation by leucocytes, and improvement of pulmonary function.

• Authors: M Okamoto, F Mitsunobu, K Ashida, T Mifune, Y Hosaki, H Tsugeno, S Harada, Y Tanizaki
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 39 Issue 2 Pg. 107-11 (Feb 2000) ISSN: 0918-2918 [Print] Japan
• PMID: 10732825 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Biomarkers
• Dietary Fats, Unsaturated
• Fatty Acids, Omega-3
• Fatty Acids, Omega-6
• Fatty Acids, Unsaturated
• Plant Oils
• alpha-Linolenic Acid
• Leukotriene B4
• Leukotriene C4
• perilla seed oil
• Corn Oil

Topics

• Adult
• Aged
• Aged, 80 and over
• Asthma (blood, diet therapy, physiopathology)
• Biomarkers (blood)
• Corn Oil (administration & dosage)
• Dietary Fats, Unsaturated (administration & dosage)
• Dietary Supplements
• Fatty Acids, Omega-3 (administration & dosage)
• Fatty Acids, Omega-6
• Fatty Acids, Unsaturated (administration & dosage)
• Female
• Humans
• Leukocytes (metabolism)
• Leukotriene B4 (blood)
• Leukotriene C4 (blood)
• Male
• Middle Aged
• Plant Oils (administration & dosage)
• Respiratory Function Tests
• Treatment Outcome
• alpha-Linolenic Acid (administration & dosage)