Octylcyanoacrylate for the treatment of contaminated partial-thickness burns in swine: a randomized controlled experiment.

Abstract

OBJECTIVE:

To compare infection and reepithelialization rates of contaminated second-degree burns treated with octylcyanoacrylate (OCA), silver sulfadiazine (SSD), polyurethane (PU) film, and dry gauze (control; C) in swine.

METHODS:

Eighty standardized burns were created by applying an aluminum bar preheated to 80 degrees C to the backs and flanks of young pigs for 20 seconds. All burns were immediately contaminated with 0.1 mL of Staphylococcus aureus 10(5)/mL and randomly treated with OCA spray, SSD, PU, or dry gauze (C). Full-thickness biopsies were taken at 3, 7, and 14 days for blinded histopathologic evaluation using hematoxylin and eosin (H&E)-stained slides. Burns were considered infected in the presence of interstitial reticular dermal neutrophils containing bacteria (intraobserver agreement, kappa = 1.00). Quantitative wound cultures were performed on a second day-3 specimen.

RESULTS:

At day 3, wound infection rates were 30% (OCA), 50% (SSD), 55% (PU), and 50% (C); p = 0.40 (Kruskal-Wallis test). At day 7, infection rates were 35% (OCA), 85% (SSD), 70% (PU), and 65% (C); p = 0.01. Median bacterial counts at day 3 were 6,500 (OCA), 20,000 (SSD), 1,000,000 (PU), and 650,000 (C); p = 0.29. The proportion of completely reepithelialized wounds at day 14 were 75% (OCA), 90% (SSD), 85% (PU), and 90% (C); p = 0.50.

CONCLUSIONS:

Treatment of contaminated partial-thickness burns with OCA spray resulted in fewer infections at one week than with the other three treatments.

• Authors: A J Singer, M Mohammad, G Tortora, H C Thode Jr, S A McClain
• Journal: Academic emergency medicine : official journal of the Society for Academic Emergency Medicine (Acad Emerg Med) Vol. 7 Issue 3 Pg. 222-7 (Mar 2000) ISSN: 1069-6563 [Print] United States
• PMID: 10730828 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Cyanoacrylates
• octylcyanoacrylate
• Sulfadiazine

Topics

• Animals
• Anti-Bacterial Agents (therapeutic use)
• Bandages
• Burns (drug therapy, microbiology)
• Cyanoacrylates (therapeutic use)
• Debridement
• Female
• Sulfadiazine (therapeutic use)
• Swine
• Treatment Outcome
• Wound Infection (drug therapy)