[Intrathecal perfusion pump with baclofen in generalized dystonia].

Abstract

OBJECTIVES:

We show the effectiveness of treatment with continuous intrathecal baclofen infusion in a case of hereditary generalized dystonia refractory to anticholinergics, tetrabenazine, pimozide, L-dopa, benzodiazepines and thalamotomy.

CLINICAL CASE:

A 26 years old female patient, when she was 11 years old began with torsion dystonia in her left feet, that progressively worsened to involve her entire body. She had painful spasms. She had four brothers, three of them with dystonia and one healthy. Her uncle grandfather had similar symptoms. Complementary explorations to reject secondary origin was negatives. She was treated with high and progressive dosages of anticholinergics, pimozide, tetrabenazine, benzodiazepines, L-dopa and thalamotomy without improvement. Underwent intrathecal baclofen test dosing, we used 25, 50, 100 micrograms/day, the last one with improvement during 10 hours. A pump was inserted with an initial dose of 220 micrograms/day. After pump insertion, baclofen dosage was gradually increased to 450 micrograms/day. She had a great improvement in right part of her body and less in her left body. Painful spasms had disappeared.

CONCLUSION:

We propose continuous baclofen intrathecal infusion pump for patients with severe torsion dystonia that not response to ordinal treatment.

• Authors: M A Grande, J Chacón, A Trujillo, J M García-Moreno, M Bravo
• Journal: Revista de neurologia (Rev Neurol) 2000 Jan 16-31 Vol. 30 Issue 2 Pg. 138-40 ISSN: 0210-0010 [Print] Spain
• Vernacular Title: Bomba de perfusión intratecal de baclofén en la distonía generalizada.
• PMID: 10730320 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Muscle Relaxants, Central
• Baclofen

Topics

• Adult
• Baclofen (administration & dosage, therapeutic use)
• Dose-Response Relationship, Drug
• Dystonia (drug therapy)
• Female
• Humans
• Infusion Pumps
• Injections, Spinal
• Muscle Relaxants, Central (administration & dosage, therapeutic use)
• Severity of Illness Index