A novel cytotoxic C-methylated biflavone from the stem of Cephalotaxus wilsoniana.

Abstract

Bioassay-directed fractionation of an ethanolic extract of Cephalotaxus wilsoniana has resulted in the isolation of a novel C-methylated biflavone, taiwanhomoflavone-A (1). Its structure was elucidated on the basis of spectroscopic analysis. Taiwanhomoflavone-A is cytotoxic with ED50 values of 3.4, 1.0, 2.0 and 2.5 microg/ml, respectively, against KB epidermoid carcinoma of nasopharynx, COLO-205 colon carcinoma, Hepa-3B hepatoma, and Hela cervix tumor cells.

• Authors: Y H Kuo, C H Lin, S Y Hwang, Y C Shen, Y L Lee, L Shyh-Yuan
• Journal: Chemical & pharmaceutical bulletin (Chem Pharm Bull (Tokyo)) Vol. 48 Issue 3 Pg. 440-1 (Mar 2000) ISSN: 0009-2363 [Print] Japan
• PMID: 10726874 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Flavonoids
• taiwanhomoflavone A

Topics

• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology)
• Drug Screening Assays, Antitumor
• Flavonoids (chemistry, isolation & purification, pharmacology)
• Humans
• Magnetic Resonance Spectroscopy
• Plant Stems (chemistry)
• Plants, Medicinal (chemistry)
• Spectrometry, Mass, Fast Atom Bombardment
• Spectrophotometry, Infrared
• Taiwan
• Tumor Cells, Cultured