Comparison of pivmecillinam and cephalexin in acute uncomplicated urinary tract infection.

Abstract

The clinical and bacteriological efficacy of a 3-day course of pivmecillinam, 200 mg three times daily, was compared with that of a 7-day course of cephalexin, 250 mg four times daily, in 216 patients with a bacteriologically confirmed, acute, uncomplicated, urinary tract infection. Both treatments were similarly effective. Clinical cure or improvement was obtained in 95.3% of patients given pivmecillinam and in 93.6% of patients given cephalexin. Bacteriological success was achieved in 89.7 and 81.7% patients taking pivmecillinam or cephalexin, respectively. Eradication rates for Escherichia coli were 90.1% for pivmecillinam and 80.6% for cephalexin. Both treatments were well tolerated. This study has confirmed that a 3-day course of pivmecillinam is effective and well tolerated in uncomplicated cystitis.

• Authors: A P Menday
• Journal: International journal of antimicrobial agents (Int J Antimicrob Agents) Vol. 13 Issue 3 Pg. 183-7 (Jan 2000) ISSN: 0924-8579 [Print] Netherlands
• PMID: 10724022 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Amdinocillin Pivoxil
• Cephalexin

Topics

• Acute Disease
• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Amdinocillin Pivoxil (administration & dosage, adverse effects, therapeutic use)
• Bacterial Infections (drug therapy, microbiology)
• Cephalexin (administration & dosage, adverse effects, therapeutic use)
• Cystitis (drug therapy, microbiology)
• Double-Blind Method
• Escherichia coli Infections (drug therapy)
• Female
• Flushing (chemically induced)
• Hot Flashes (chemically induced)
• Humans
• Male
• Middle Aged
• Nausea (chemically induced)
• Urinary Tract Infections (drug therapy, microbiology)