Association of the alpha-adducin polymorphism with blood pressure and risk of myocardial infarction.

Abstract

Genetic variation in adducin, a protein associated with the inner leaflet of the plasma membrane, may be in part responsible for salt-sensitive hypertension. In the Netherlands, 560 men who survived a myocardial infarction and 646 men who had undergone an orthopaedic intervention participated in a case-control study. In men in this study, the alpha-adducin polymorphism was not associated with the risk of myocardial infarction either among those with or among those without a clinical history of hypertension. In a cross-sectional analysis of blood pressure data from the controls, the alpha-adducin polymorphism was associated neither with self-reported hypertension (OR = 0.78, 95% CI = 0.51-1.19) nor with mean levels of systolic or diastolic blood pressure. Additional studies in other populations are needed to assess the contribution of alpha-adducin to high blood pressure and cardiovascular risk.

• Authors: B M Psaty, C Doggen, H L Vos, J P Vandenbroucke, F R Rosendaal
• Journal: Journal of human hypertension (J Hum Hypertens) Vol. 14 Issue 2 Pg. 95-7 (Feb 2000) ISSN: 0950-9240 [Print] England
• PMID: 10723114 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Calmodulin-Binding Proteins
• adducin

Topics

• Aged
• Blood Pressure (genetics)
• Calmodulin-Binding Proteins (genetics, physiology)
• Case-Control Studies
• Cross-Sectional Studies
• Gene Frequency
• Genetic Predisposition to Disease
• Humans
• Male
• Middle Aged
• Myocardial Infarction (genetics)
• Polymorphism, Genetic
• Risk Factors