Abstract | BACKGROUND/AIMS: METHODS: The medical records and histopathological slides of 15 patients (8 men and 7 women) with documented DBDA after curative pancreaticoduodenectomy were reviewed. RESULTS: Nine standard and 6 pylorus-preserving pancreaticoduodenectomies were performed. TNM staging included 1, 3, 2, 8, and 1 patient in stages I, II, III, and IVA and IVB, respectively. Lymphatic and perineural invasion was present in 4 (27%) and 9 (60%) patients, respectively. With multivariate analysis only serum bilirubin was a significant prognostic factor. Median survival was 21 months, and 2- and 5-year actuarial survivals were 40 and 20%, respectively. Median survival with adjuvant therapy (n = 6) was 21 months, with 5-year survival of 33%. Five-year actuarial survivals when lymphatic or perineural invasion was present were 0 and 11%, respectively. CONCLUSION:
DBDA is aggressive, but entails a better prognosis than pancreatic ductal or more proximal bile duct carcinoma. Lymphatic and/or perineural invasion worsen survival.
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Authors | L Bortolasi, L J Burgart, G G Tsiotos, E Luque-De León, M G Sarr |
Journal | Digestive surgery
(Dig Surg)
Vol. 17
Issue 1
Pg. 36-41
( 2000)
ISSN: 0253-4886 [Print] Switzerland |
PMID | 10720830
(Publication Type: Journal Article)
|
Copyright | Copyright 2000 S. Karger AG, Basel |
Chemical References |
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Topics |
- Aged
- Bilirubin
(blood)
- Cholangiocarcinoma
(pathology, surgery)
- Common Bile Duct Neoplasms
(pathology, surgery)
- Female
- Humans
- Lymphatic Metastasis
- Male
- Multivariate Analysis
- Neoplasm Invasiveness
- Pancreaticoduodenectomy
- Prognosis
- Survival Rate
- Time Factors
- Treatment Outcome
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