Hypoglycaemic and other related actions of Tinospora cordifolia roots in alloxan-induced diabetic rats.

Abstract

Tinospora cordifolia is widely used in Indian Ayurvedic medicine for treating diabetes mellitus. Oral administration of an aqueous T. cordifolia root extract (TCREt) to alloxan diabetic rats caused a significant reduction in blood glucose and brain lipids. The extract caused an increase in body weight, total haemoglobin and hepatic hexokinase. The root extract also lowers hepatic glucose-6-phosphatase and serum acid phosphatase, alkaline phosphatase, and lactate dehydrogenase in diabetic rats. Thus TCREt has hypoglycaemic and hypolipidaemic effect.

• Authors: P Stanely, M Prince, V P Menon
• Journal: Journal of ethnopharmacology (J Ethnopharmacol) Vol. 70 Issue 1 Pg. 9-15 (Apr 2000) ISSN: 0378-8741 [Print] Ireland
• PMID: 10720784 (Publication Type: Journal Article)

Chemical References

• Blood Glucose
• Enzymes
• Fatty Acids, Nonesterified
• Hemoglobins
• Hypoglycemic Agents
• Phospholipids
• Cholesterol

Topics

• Animals
• Blood Glucose (metabolism)
• Brain Chemistry (drug effects)
• Cholesterol (blood)
• Diabetes Mellitus, Experimental (drug therapy, enzymology)
• Enzymes (blood, metabolism)
• Fatty Acids, Nonesterified (blood)
• Hemoglobins (metabolism)
• Hypoglycemic Agents (therapeutic use)
• India
• Lipid Metabolism
• Liver (drug effects, enzymology)
• Male
• Phospholipids (blood)
• Plant Roots
• Plants, Medicinal (chemistry)
• Rats
• Rats, Wistar