Immature rat convulsions and long-term effects on hippocampal cholinergic neurotransmission.

Generalized tonic-clonic convulsions were induced on 2 consecutive days by pentylenetetrazol (PTZ) in immature rats (postnatal days 10 and 20), and hippocampal slices were prepared at different intervals post-injection. The anticholinesterase eserine provoked interictal-like discharges in the CA3 area of PTZ-injected rats (19/33), but not in controls (0/15), an effect mimicked by carbachol and reversed by atropine. This enhanced response to eserine was recorded in slices from 25-100% of the PTZ-injected rats, the percentage varying with the age at injection and post-injection interval. These results suggest that seizures in immature brain may have long-term consequences in cholinergic neurotransmission, converting a rise in endogenous ACh into an epileptogenic stimulus, which in turn would presumably facilitate the recurrence of seizures.
AuthorsS Meilleur, L Carmant, C Psarropoulou
JournalNeuroreport (Neuroreport) Vol. 11 Issue 3 Pg. 521-4 (Feb 28 2000) ISSN: 0959-4965 [Print] ENGLAND
PMID10718307 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Cholinesterase Inhibitors
  • Convulsants
  • Physostigmine
  • Acetylcholine
  • Pentylenetetrazole
  • Acetylcholine (metabolism)
  • Animals
  • Animals, Newborn (physiology)
  • Cholinergic Fibers (drug effects, physiology)
  • Cholinesterase Inhibitors (pharmacology)
  • Convulsants
  • Excitatory Postsynaptic Potentials (drug effects)
  • Hippocampus (drug effects, physiopathology)
  • In Vitro Techniques
  • Pentylenetetrazole
  • Physostigmine (pharmacology)
  • Rats
  • Rats, Sprague-Dawley
  • Seizures (chemically induced, physiopathology)
  • Synaptic Transmission (drug effects)
  • Time Factors

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