Abstract | BACKGROUND: Mucosal surface hydrophobicity is a key factor of the gastric acid defence barrier. In the colon, surface hydrophobicity is high but its biological function remains unexplored. AIMS: METHODS: RESULTS: In controls, surface hydrophobicity was low on the caecal mucosa and high in colon and rectum. Detergent treatment reduced surface hydrophobicity, and increased colonic permeability to mannitol and dextran. Conversely, treatment with lipids increased surface hydrophobicity, and reduced colonic permeability. Administration of DSS induced a progressive loss of colonic surface hydrophobicity, and an increase in permeability to mannitol and dextran. Detergent treatment increased susceptibility to epithelial damage and mucosal inflammation by DSS. Treatment with lipids reduced susceptibility to DSS colitis. CONCLUSION: Colonic surface hydrophobicity modulates permeability to hydrophilic molecules and protects against toxins.
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Authors | A Lugea, A Salas, J Casalot, F Guarner, J R Malagelada |
Journal | Gut
(Gut)
Vol. 46
Issue 4
Pg. 515-21
(Apr 2000)
ISSN: 0017-5749 [Print] England |
PMID | 10716681
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Phospholipids
- Mannitol
- Dextran Sulfate
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Topics |
- Animals
- Cell Membrane Permeability
(physiology)
- Colon
- Dextran Sulfate
(pharmacokinetics)
- Intestinal Absorption
- Intestinal Mucosa
(physiology)
- Male
- Mannitol
(pharmacokinetics)
- Phospholipids
(physiology)
- Rats
- Rats, Sprague-Dawley
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