Abstract |
The therapeutic effect of oral tilmicosin was compared with enrofloxacin, and the efficacy of three doses of the drug was examined in two fully randomized blinded field trials. Pneumonic milk-fed calves between 3 days and 2.5 months of age were allocated into two groups in trial 1 (50 animals) and into three groups in trial 2 (69 calves). In the first trial, the animals were treated with 25 mg/kg/day tilmicosin or 2.5 mg/kg/day enrofloxacin in milk for 5 days. In the second trial, the calves received either 25 mg/kg/day tilmicosin for 5 days or 3 days, or else 12.5 mg/kg tilmicosin for 5 days. All calves were clinically examined for 10 days. In the first trial, oral tilmicosin at a dose of 25 mg/kg/day for 5 days proved to be effective for the treatment of endemic pasteurellosis of milk-fed calves. The efficacy was the same as that of enrofloxacin. All three doses in the second trial were effective and were statistically equivalent to the original dose tested.
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Authors | L Fodor, L Reeve-Johnson, A Hodge, J Varga |
Journal | Veterinary journal (London, England : 1997)
(Vet J)
Vol. 159
Issue 2
Pg. 194-200
(Mar 2000)
ISSN: 1090-0233 [Print] England |
PMID | 10712808
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Copyright | Copyright 2000 Harcourt Publishers Ltd. |
Chemical References |
- Anti-Bacterial Agents
- Anti-Infective Agents
- Fluoroquinolones
- Macrolides
- Quinolones
- Enrofloxacin
- tilmicosin
- Tylosin
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Topics |
- Administration, Oral
- Animals
- Animals, Newborn
- Anti-Bacterial Agents
(administration & dosage)
- Anti-Infective Agents
(administration & dosage)
- Cattle
- Cattle Diseases
(drug therapy)
- Enrofloxacin
- Female
- Fluoroquinolones
- Macrolides
- Male
- Pneumonia, Bacterial
(drug therapy, veterinary)
- Quinolones
(administration & dosage)
- Treatment Outcome
- Tylosin
(administration & dosage, analogs & derivatives)
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