Abstract | BACKGROUND: METHODS: 4327 schoolchildren (aged 5-14 years), assigned by block randomisation of classrooms, received standard titre doses of either Schwarz or Edmonston-Zagreb measles vaccines subcutaneously or by aerosol. Blood samples for antibody assay were collected before vaccination, at 1 month, and 1 year after vaccination. The main endpoints (antibody titres at 1 month and 1 year) were compared between groups. FINDINGS: 992 children had antibody titre data available for all timepoints. 14 (3.6%) of 385 children who received Edmonston-Zagreb vaccine by aerosol were seronegative 1 year after vaccination, compared with 28 (8.6%) of 326 children who received Edmonston-Zagreb subcutaneous vaccine and 39 (13.9%) of 281 children who received Schwarz subcutaneous vaccine. At 1 month, 326 (84.7%) children who received aerosol Edmonston-Zagreb vaccine had seroconverted, compared with 257 (78.8%) who received subcutaneous Edmonston-Zagreb vaccine and 176 (62.6%) who received subcutaneous Schwarz vaccine. At 1 month, only 116 (22.7%) of 511 children in the Schwarz aerosol group had seroconverted; this aerosol vaccine had no detectable potency after 2 min of nebulisation. There were no serious side-effects: about 5% of children in each group had a rash within 2 weeks of vaccination. INTERPRETATION: An aerosol vaccination method that uses currently available devices and a suitably stable vaccine is effective and acceptable. This form of delivery is adaptable to mass campaigns, avoids the risks associated with injections, and could help measles eradication.
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Authors | A Dilraj, F T Cutts, J F de Castro, J G Wheeler, D Brown, C Roth, H M Coovadia, J V Bennett |
Journal | Lancet (London, England)
(Lancet)
Vol. 355
Issue 9206
Pg. 798-803
(Mar 04 2000)
ISSN: 0140-6736 [Print] England |
PMID | 10711928
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Aerosols
- Antibodies, Viral
- Measles Vaccine
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Topics |
- Administration, Inhalation
- Adolescent
- Aerosols
- Antibodies, Viral
(blood)
- Child
- Child, Preschool
- Female
- Follow-Up Studies
- Humans
- Immunization, Secondary
- Injections, Subcutaneous
- Male
- Measles
(immunology, prevention & control)
- Measles Vaccine
(administration & dosage, adverse effects, immunology)
- Measles virus
(immunology)
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