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Epichlorohydrin induced biochemical changes in the rose-ringed parakeet, Psittacula krameri Scopoli.

Abstract
Intraperitoneal administration of epichlorohydrin (ECH) at the dose level of 20 and 50 mg/kg body weight inhibited spermatogenesis in the testis of parakeet during breeding season. A total load of 60 mg/kg body weight of ECH given on 3 consecutive days proved to be lethal. Testicular proteins, nucleic acids (DNA and RNA), phospholipids and acid phosphatase activity were decreased, while the lipids, total cholesterol and alkaline phosphatase activity increased after ECH administration. The results suggest that the testicular atrophy caused by ECH was associated with an alteration in the activities of macromolecules and enzymes related to specific events of spermatogenesis.
AuthorsB Hans, S Kaur, G K Sangha
JournalIndian journal of experimental biology (Indian J Exp Biol) Vol. 37 Issue 8 Pg. 774-7 (Aug 1999) ISSN: 0019-5189 [Print] India
PMID10709325 (Publication Type: Journal Article)
Chemical References
  • Epichlorohydrin
Topics
  • Animals
  • Birds (physiology)
  • Dose-Response Relationship, Drug
  • Epichlorohydrin (pharmacology)
  • Male
  • Spermatogenesis (drug effects)

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