Abstract |
In order to decrease toxicity and/or increase radiosensitizing activity, a new 2-nitroimidazole derivative, methyl 2-nitroimidazole-1-acetohydroxamate (KIN-804), was synthesized to solve the problem of tumor hypoxia. Evaluation of the efficiency of KIN-804 was carried out through studying the antioxidant enzyme system: The superoxide dismutase (SOD), catalase and lipid peroxide levels provide a rough index of the balance between free radical generation and scavenging. Female albino mice were inoculated with Ehrlich ascites carcinoma (EAC) in the thigh. The administration of KIN-804 (i.p. 80 mg/kg body weight) was carried out 20 min before localized irradiation of 10 Gy. In general, the data revealed that KIN-804 administration, followed or not by gamma irradiation, exerted significant inhibition of SOD and catalase activities accompanied by a significant increase in lipid peroxide level in tumor-bearing mice.
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Authors | M Abu-Zeid, H Hori, H Nagasawa, Y Uto, S Inayama |
Journal | Biological & pharmaceutical bulletin
(Biol Pharm Bull)
Vol. 23
Issue 2
Pg. 195-8
(Feb 2000)
ISSN: 0918-6158 [Print] Japan |
PMID | 10706383
(Publication Type: Journal Article)
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Chemical References |
- Antioxidants
- Hydroxamic Acids
- Lipid Peroxides
- Nitroimidazoles
- Radiation-Sensitizing Agents
- 2-nitroimidazole-1-methylacetohydroxamate
- Catalase
- Superoxide Dismutase
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Topics |
- Animals
- Antioxidants
(metabolism)
- Carcinoma, Ehrlich Tumor
(enzymology)
- Catalase
(blood, metabolism, radiation effects)
- Female
- Hydroxamic Acids
(pharmacology)
- Hypoxia
(enzymology)
- Lipid Peroxides
(blood, metabolism, radiation effects)
- Liver
(enzymology)
- Lung
(enzymology)
- Mice
- Nitroimidazoles
(pharmacology)
- Radiation-Sensitizing Agents
(pharmacology)
- Superoxide Dismutase
(blood, metabolism, radiation effects)
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