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Studies of methyl 2-nitroimidazole-1-acetohydroxamate (KIN-804) 2: effect on certain antioxidant enzyme systems in mice bearing Ehrlich ascites carcinoma.

Abstract
In order to decrease toxicity and/or increase radiosensitizing activity, a new 2-nitroimidazole derivative, methyl 2-nitroimidazole-1-acetohydroxamate (KIN-804), was synthesized to solve the problem of tumor hypoxia. Evaluation of the efficiency of KIN-804 was carried out through studying the antioxidant enzyme system: The superoxide dismutase (SOD), catalase and lipid peroxide levels provide a rough index of the balance between free radical generation and scavenging. Female albino mice were inoculated with Ehrlich ascites carcinoma (EAC) in the thigh. The administration of KIN-804 (i.p. 80 mg/kg body weight) was carried out 20 min before localized irradiation of 10 Gy. In general, the data revealed that KIN-804 administration, followed or not by gamma irradiation, exerted significant inhibition of SOD and catalase activities accompanied by a significant increase in lipid peroxide level in tumor-bearing mice.
AuthorsM Abu-Zeid, H Hori, H Nagasawa, Y Uto, S Inayama
JournalBiological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 23 Issue 2 Pg. 195-8 (Feb 2000) ISSN: 0918-6158 [Print] Japan
PMID10706383 (Publication Type: Journal Article)
Chemical References
  • Antioxidants
  • Hydroxamic Acids
  • Lipid Peroxides
  • Nitroimidazoles
  • Radiation-Sensitizing Agents
  • 2-nitroimidazole-1-methylacetohydroxamate
  • Catalase
  • Superoxide Dismutase
Topics
  • Animals
  • Antioxidants (metabolism)
  • Carcinoma, Ehrlich Tumor (enzymology)
  • Catalase (blood, metabolism, radiation effects)
  • Female
  • Hydroxamic Acids (pharmacology)
  • Hypoxia (enzymology)
  • Lipid Peroxides (blood, metabolism, radiation effects)
  • Liver (enzymology)
  • Lung (enzymology)
  • Mice
  • Nitroimidazoles (pharmacology)
  • Radiation-Sensitizing Agents (pharmacology)
  • Superoxide Dismutase (blood, metabolism, radiation effects)

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