Abstract |
We investigated the effect of ferulic acid (FA) and isoferulic acid (IFA), which are the main active components of the rhizoma of Cimicifuga heracleifolia (CH), an anti-inflammatory drug used frequently in Japanese traditional medicine, on the production of macrophage inflammatory protein-2 (MIR-2) in a murine macrophage cell line, RAW264.7, in response to respiratory syncytial virus ( RSV) infection. Following the exposure of cells to RSV for 20h, the MIP-2 level in condition medium was increased to about 20 ng/ml, although this level in mock-infected cells was negligible. In the presence of either FA or IFA, RSV-infected cells reduced MIP-2 production in a dose-dependent manner. These data suggest that FA and IFA might be responsible, at least in part, for the anti-inflammatory drug effect of CH extract through the inhibition of MIP-2 production.
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Authors | S Sakai, H Kawamata, T Kogure, N Mantani, K Terasawa, M Umatake, H Ochiai |
Journal | Mediators of inflammation
(Mediators Inflamm)
Vol. 8
Issue 3
Pg. 173-5
( 1999)
ISSN: 0962-9351 [Print] United States |
PMID | 10704056
(Publication Type: Journal Article)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Chemokine CXCL2
- Chemokines
- Cinnamates
- Coumaric Acids
- Cxcl2 protein, mouse
- ferulic acid
- isoferulic acid
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Topics |
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
(pharmacology)
- Cell Line
- Chemokine CXCL2
- Chemokines
(biosynthesis, metabolism)
- Cinnamates
(pharmacology)
- Coumaric Acids
(pharmacology)
- Macrophages
(drug effects, physiology, virology)
- Mice
- Respiratory Syncytial Viruses
(physiology)
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