Abstract | PURPOSE: METHODS AND MATERIALS: From July 1997 through June 1998, 17 patients with head and neck cancer receiving primary or adjuvant irradiation were randomized to either glutamine suspension (16 g in 240 ml normal saline) (n = 8) or placebo ( normal saline) (n = 9) arm. Patients were instructed to swish the test solutions (30 ml) four times per day. All patients received half-mouth irradiation at least. Patients were treated 1.8 Gy per fraction daily, 5 days a week. We evaluated the grading of oral mucositis daily fraction at each day of treatment until 45 Gy/25 fractions. World Health Organization (WHO) step analgesic medication and body weight change were compared between the two arms. RESULTS: The duration of objective oral mucositis > or = Grade 1 (p = 0.0097), Grade 2 (p = 0.0232), and Grade 3 (p = 0.0168) was shorter in the glutamine arm. Mean maximum grade of objective oral mucositis was less severe in the glutamine arm (1.6 vs. 2.6) (p = 0.0058). Glutamine did not reduce the duration and severity of subjective oral mucositis except for duration > or = Grade 3 (p = 0.0386). In the analysis of mean maximum WHO step of analgesic medication, there was no statistical difference (p = 0.5374) between the two arms. Mean body weight change was also not significantly different (p = 0.8070). CONCLUSIONS:
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Authors | E Y Huang, S W Leung, C J Wang, H C Chen, L M Sun, F M Fang, S A Yeh, H C Hsu, C Y Hsiung |
Journal | International journal of radiation oncology, biology, physics
(Int J Radiat Oncol Biol Phys)
Vol. 46
Issue 3
Pg. 535-9
(Feb 01 2000)
ISSN: 0360-3016 [Print] United States |
PMID | 10701731
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Administration, Oral
- Body Weight
- Female
- Glutamine
(administration & dosage)
- Head and Neck Neoplasms
(radiotherapy)
- Humans
- Male
- Middle Aged
- Pilot Projects
- Radiation Injuries
(drug therapy)
- Stomatitis
(drug therapy, etiology, pathology)
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