Abstract |
Testosterone substitution, needed for normal physical development in male hypogonadal adolescents, does not induce testicular growth. We treated 37 hypogonadal adolescents with gonadotropins (hCG/hMG), to obtain complete virilization during the first two years of treatment, to avoid psychological sequellae and to allow normal sexual development. Testicular volume increased significantly during therapy (from 1.98 +/- 1.2 to 9 +/- 3.3 ml), while testosterone rose from 0.26 +/- 0.04 to 5.3 +/- 0.8 ng/ml, with worse results in adolescents with cryptorchidism. hCG/hMG treatment had a better outcome than testosterone during the induction of puberty, avoiding psychological problems induced by atrophic testes. Further long term studies are necessary to evaluate whether early hCG/hMG treatment facilitates later spermatogenesis even in patients with cryptorchidism.
|
Authors | C Bouvattier, M Tauber, B Jouret, J L Chaussain, P Rochiccioli |
Journal | Journal of pediatric endocrinology & metabolism : JPEM
(J Pediatr Endocrinol Metab)
Vol. 12 Suppl 1
Pg. 339-44
(Apr 1999)
ISSN: 0334-018X [Print] Germany |
PMID | 10698599
(Publication Type: Clinical Trial, Journal Article)
|
Chemical References |
- Chorionic Gonadotropin
- Testosterone
- Menotropins
|
Topics |
- Adolescent
- Adult
- Body Height
(drug effects)
- Chorionic Gonadotropin
(administration & dosage, adverse effects, pharmacology, therapeutic use)
- Cryptorchidism
(complications, drug therapy, pathology, psychology)
- Drug Therapy, Combination
- Hormone Replacement Therapy
- Humans
- Hypogonadism
(complications, drug therapy, physiopathology, psychology)
- Libido
(drug effects)
- Male
- Menotropins
(administration & dosage, adverse effects, pharmacology, therapeutic use)
- Puberty
(drug effects, metabolism, physiology, psychology)
- Sexual Maturation
(drug effects, physiology)
- Sperm Count
(drug effects)
- Testis
(drug effects, growth & development, pathology, physiopathology)
- Testosterone
(administration & dosage, blood, pharmacology, therapeutic use)
|