Central nervous system manifestations of an ibuprofen overdose reversed by naloxone.

Abstract

Ibuprofen overdose is usually characterized by GI upset, dizziness, and mild sedation. On rare occasions, severe complications such as respiratory failure, metabolic acidosis, renal failure, coma, and death have been reported in both adults and children. Presently, treatment of acute ibuprofen intoxication with complications requires supportive therapy until the symptoms resolve over 24 to 48 hours. We report the case of an 11-month-old female infant with a depressed level of consciousness after ingestion of ibuprofen whose mental status markedly improved with administration of naloxone.

• Authors: R B Easley, W A Altemeier 3rd
• Journal: Pediatric emergency care (Pediatr Emerg Care) Vol. 16 Issue 1 Pg. 39-41 (Feb 2000) ISSN: 0749-5161 [Print] United States
• PMID: 10698143 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Antidotes
• Naloxone
• Ibuprofen

Topics

• Acidosis (chemically induced)
• Anti-Inflammatory Agents, Non-Steroidal (poisoning)
• Antidotes (pharmacology, therapeutic use)
• Central Nervous System (drug effects)
• Central Nervous System Diseases (chemically induced, drug therapy)
• Drug Overdose (drug therapy)
• Female
• Humans
• Ibuprofen (poisoning)
• Infant
• Naloxone (pharmacology, therapeutic use)