The role of preoperative subconjunctival mydricaine and topical diclofenac sodium 0.1% in maintaining mydriasis during vitrectomy.

Abstract

PURPOSE:

To establish the role of preoperative subconjunctival mydricaine and diclofenac 0.1% in maintaining mydriasis during vitrectomy.

METHODS:

Fifty-seven patients were entered into the study. All were given cyclopentolate 1% and phenylephrine 2.5% preoperatively. Each patient was randomly allocated to one of three groups. In Group 1, patients received mydricaine by subconjunctival injection and diclofenac 0.1% topically preoperatively. In Group 2, patients received only subconjunctival mydricaine. Group 3 patients received only topical diclofenac preoperatively. Pupil diameter was measured with calipers before and at the end of the operation.

RESULTS:

There was no statistically significant difference in the change in pupil size between Groups 2 and 3. In all patients in Group 1 (who received both subconjunctival mydricaine and diclofenac preoperatively), pupil size was either maintained or increased after vitrectomy. This result was statistically significant when compared with the other groups (for Group 1 versus Group 2, P<0.005; for Group 1 versus Group 3, P<4.7x10(-06)).

CONCLUSION:

Topical diclofenac is useful for maintaining pupil size during vitrectomy only when used in conjunction with subconjunctival mydricaine, especially in patients in whom prolonged surgery is anticipated.

• Authors: M K Kulshrestha, S Rauz, R R Goble, I A Stavrakas, G R Kirkby
• Journal: Retina (Philadelphia, Pa.) (Retina) Vol. 20 Issue 1 Pg. 46-51 ( 2000) ISSN: 0275-004X [Print] United States
• PMID: 10696747 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Anesthetics, Local
• Cyclooxygenase Inhibitors
• Drug Combinations
• Mydriatics
• Ophthalmic Solutions
• Diclofenac
• Procaine
• Atropine
• Epinephrine

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Anesthetics, Local (administration & dosage)
• Atropine (administration & dosage)
• Cyclooxygenase Inhibitors (administration & dosage)
• Diclofenac (administration & dosage)
• Drug Combinations
• Epinephrine (administration & dosage)
• Female
• Humans
• Injections
• Iris (drug effects)
• Male
• Middle Aged
• Mydriatics (administration & dosage)
• Ophthalmic Solutions
• Preoperative Care
• Procaine (administration & dosage)
• Pupil (drug effects)
• Treatment Outcome
• Vitrectomy (methods)