[Protective effect of a new antiviral preparation of phosprenyl in experimental tick-borne encephalitis].

Abstract

Antiviral activity of phosprenyl was studied in BALB/c mice infected with tick-borne encephalitis (TBE) virus. Up to 60% animals infected with TBE virus survived after 1-3 intramuscular injections of phosprenyl. The mortality in the untreated group infected with the virus was 100%. Direct antiviral effect of phosprenyl was studied in sensitive SPEV cells infected with TBE virus. The titer of the virus decreased 10-fold in the cells treated with the drug vs. untreated control cells. Phosprenyl stimulates some interleukins: gamma-interferon, tumor necrosis factor-alpha, and interleukin-6. The stimulating effect of the drug manifests in intact animals and in those infected with TBE virus and treated with phosprenyl. The prospects of further trials of the drug as a therapeutic and prophylactic agent in TBE are discussed.

• Authors: S V Ozherelkov, A V Timofeev, G P Novikova, A V Deeva, A N Narovlianskiĭ, A V Sanin, A V Pronin
• Journal: Voprosy virusologii (Vopr Virusol) 2000 Jan-Feb Vol. 45 Issue 1 Pg. 33-7 ISSN: 0507-4088 [Print] Russia (Federation)
• Vernacular Title: Zashchitnoe deĭstvie novogo protivovirusnogo preparata fosprenil pri éksperimental'nom kleshchevom éntsefalite.
• PMID: 10695042 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antiviral Agents
• Cytokines
• Polyisoprenyl Phosphates
• phosprenyl

Topics

• Animals
• Antiviral Agents (administration & dosage, therapeutic use)
• Cytokines (biosynthesis)
• Encephalitis, Tick-Borne (prevention & control)
• Injections, Intramuscular
• Mice
• Mice, Inbred BALB C
• Polyisoprenyl Phosphates (administration & dosage, therapeutic use)