Abstract | PURPOSE: PATIENTS AND METHODS: The pharmacokinetics of nelarabine and/or ara-G were evaluated in 71 patients (25 pediatric and 46 adult patients) on the first day of therapy. Blood was collected at specified times for the determination of plasma nelarabine and ara-G concentrations. RESULTS: There were no statistically significant differences in the pharmacokinetics of nelarabine between any of the groups of patients. The harmonic mean half-life (t1/2) of nelarabine in pediatric and adult patients was 14.1 minutes and 16.5 minutes, respectively. The maximum concentrations (C(max)) of ara-G occurred at or near the end of the nelarabine infusion. The C(max) of ara-G ranged from 11.6 micromol/L to 308.7 micromol/L at nelarabine doses of 5 to 75 mg/kg and was linearly related to the nelarabine dose. No statistically significant differences were noted for the pharmacokinetic parameter estimates of ara-G between adult male and female patients. In children versus adults, the dose-normalized C(max), time of the C(max), and the steady-state volume of distribution of ara-G were similar. However, the clearance of ara-G was higher in pediatric patients (0.312 L.h(-1).kg(-1)) as compared with adult patients (0. 213 L.h(-1).kg(-1)) (P <.001). The t1/2 of ara-G was shorter in pediatric patients as compared with adult patients (2.1 hours v 3.0 hours; P <.01). CONCLUSION:
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Authors | D F Kisor, W Plunkett, J Kurtzberg, B Mitchell, J P Hodge, T Ernst, M J Keating, V Gandhi |
Journal | Journal of clinical oncology : official journal of the American Society of Clinical Oncology
(J Clin Oncol)
Vol. 18
Issue 5
Pg. 995-1003
(Mar 2000)
ISSN: 0732-183X [Print] United States |
PMID | 10694549
(Publication Type: Clinical Trial, Clinical Trial, Phase I, Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antineoplastic Agents
- Arabinonucleosides
- 9-arabinofuranosylguanine
- nelarabine
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Topics |
- Adolescent
- Adult
- Aged
- Antineoplastic Agents
(pharmacokinetics, therapeutic use)
- Arabinonucleosides
(pharmacokinetics, therapeutic use)
- Child
- Child, Preschool
- Female
- Hematologic Neoplasms
(drug therapy, metabolism)
- Humans
- Male
- Middle Aged
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