Abstract | PURPOSE: DESIGN: Retrospective nonrandomized comparative trial with historical controls. PARTICIPANTS AND CONTROLS: Ten patients with unilateral iridocorneal endothelial ( ICE) syndrome were reviewed. Their intraocular pressures could not be controlled medically. In five eyes, this was the primary surgery performed. Five of the patients had undergone prior intraocular pressure-(IOP) lowering surgery that had failed at the time enrolled. Results were compared with previously published case series of similar patients treated with trabeculectomy alone or trabeculectomy and subconjunctival 5-fluorouracil injections. INTERVENTION: Intervention consisted of trabeculectomy with a limbus-based conjunctival flap and mitomycin-C application. The dosage of mitomycin-C was 0.4 mg/ml for 1 to 4 minutes (mean, 1.9 min). MAIN OUTCOME MEASURES: Adequate control of IOP (without medication lower than 21 mm Hg). RESULTS: In eight eyes the IOP remained well controlled (mean IOP, 12.1 mm Hg) over the entire length of available of follow-up (mean, 14.9 months). Two eyes required implantation of an aqueous tube shunt at 4 and 11 months, respectively, after trabeculectomy with mitomycin-C. One eye experienced visual loss of 3 Snellen lines because of hypotony maculopathy. CONCLUSIONS:
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Authors | I M Lanzl, R P Wilson, D Dudley, J J Augsburger, I M Aslanides, G L Spaeth |
Journal | Ophthalmology
(Ophthalmology)
Vol. 107
Issue 2
Pg. 295-7
(Feb 2000)
ISSN: 0161-6420 [Print] United States |
PMID | 10690828
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Antibiotics, Antineoplastic
- Mitomycin
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Topics |
- Adult
- Aged
- Antibiotics, Antineoplastic
(therapeutic use)
- Combined Modality Therapy
- Corneal Diseases
(complications, pathology)
- Endothelium, Corneal
(pathology)
- Female
- Follow-Up Studies
- Glaucoma
(etiology, therapy)
- Humans
- Intraocular Pressure
- Iris Diseases
(complications)
- Male
- Middle Aged
- Mitomycin
(therapeutic use)
- Retrospective Studies
- Syndrome
- Trabeculectomy
- Treatment Outcome
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