Effect of rooperol on collagen synthesis and cell growth.

Abstract

The effect of rooperol on type I collagen synthesis in normal skin and lung fibroblasts and cell growth in normal and transformed fibroblasts was investigated. Low concentrations of rooperol selectively inhibited the growth of transformed cells while stimulating collagen synthesis in normal fibroblasts. Elevated collagen synthesis and deposition could impede tumour cell invasion and metastasis, implying that rooperol may be useful as an antimetastatic agent in the treatment of cancer.

• Authors: E Dietzsch, C F Albrecht, M I Parker
• Journal: IUBMB life (IUBMB Life) Vol. 48 Issue 3 Pg. 321-5 (Sep 1999) ISSN: 1521-6543 [Print] England
• PMID: 10690646 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Catechols
• Cyclooxygenase Inhibitors
• rooperol
• Collagen

Topics

• Catechols (pharmacology)
• Cell Division (drug effects)
• Cell Line
• Collagen (biosynthesis)
• Cyclooxygenase Inhibitors (pharmacology)
• Fibroblasts (metabolism)
• Humans
• Lung (metabolism)
• Skin (metabolism)