Abstract |
Following surgery on fallopian tubes, the development of adhesions is a natural consequence of wound healing and may result in infertility. Using a rabbit model, we evaluated the anti-adhesive properties of a sponge-like equine collagen sheet ( TachoComb), which is coated on one side with human fibrinogen and bovine thrombin. TachoComb is applied by affixing the sheet over the area of perforation or bleeding and acts as a haemostatic agent, capable of sealing perforations to prevent leakage. In our rabbit model, adhesions were induced by mechanical and chemical irritants during laparotomy. After a 1-month recovery period, adhesions were lysed using microsurgical techniques and TachoComb, or physiological saline applied. Evaluation of adhesion reformation was determined after a minimum of 10 days. TachoComb significantly reduced the area of adhesion reformation compared with rabbits treated using physiological saline only. Our study demonstrated that TachoComb is effective not only as a haemostatic agent, but is also capable of reducing adhesion reformation.
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Authors | H Osada, M Minai, T Yoshida, K Satoh |
Journal | The Journal of international medical research
(J Int Med Res)
1999 Sep-Oct
Vol. 27
Issue 5
Pg. 242-6
ISSN: 0300-0605 [Print] England |
PMID | 10689630
(Publication Type: Journal Article)
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Chemical References |
- Drug Combinations
- tachocomb
- Fibrinogen
- Aprotinin
- Thrombin
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Topics |
- Animals
- Aprotinin
(pharmacology)
- Cattle
- Drug Combinations
- Fallopian Tubes
(surgery)
- Female
- Fibrinogen
(pharmacology)
- Humans
- Postoperative Complications
(prevention & control)
- Rabbits
- Thrombin
(pharmacology)
- Tissue Adhesions
(prevention & control)
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