Anti-inflammatory glycoterpenoids from Scrophularia auriculata.

The activity of the four glycoterpenoids: two saponins, verbascosaponin A and verbascosaponin, and two iridoids, scropolioside A and scrovalentinoside, isolated from Scrophularia auriculata ssp. pseudoauriculata, were studied in different models of acute and chronic inflammation. Both saponins significantly inhibited the mouse paw edema induced by carrageenan and ear edema induced by single and multiple doses of 12-O-tetradecanoylphorbol 13-acetate (TPA). Verbascosaponin A showed a potency twice as high as that of indomethacin in the acute TPA model. Verbascosaponin A and scropolioside A were active after a long latency period against ethyl phenylpropiolate edema, as are glucocorticoids. When the putative corticoid-like mechanism of the two compounds was studied, verbascosaponin A activity was notably reduced by the mRNA synthesis inhibitor, actinomycin D, while the effect of scropolioside A was partially interfered with by the anti-glucocorticoid drugs used. Both iridoids were active on the delayed type hypersensitivity reaction. They significantly reduced the inflammatory lesion and suppressed the cellular infiltration.
AuthorsR M Giner, M L Villalba, M C Recio, S Máñez, M Cerdá-Nicolás, J Ríos
JournalEuropean journal of pharmacology (Eur J Pharmacol) Vol. 389 Issue 2-3 Pg. 243-52 (Feb 18 2000) ISSN: 0014-2999 [Print] NETHERLANDS
PMID10688990 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Inflammatory Agents
  • Glucosides
  • Glycosides
  • Iridoid Glycosides
  • Iridoids
  • Pyrans
  • Saponins
  • Terpenes
  • Triterpenes
  • scrovalentinoside
  • scropolioside A
  • Serotonin
  • verbascosaponin
  • Tetradecanoylphorbol Acetate
  • Animals
  • Anti-Inflammatory Agents (pharmacology)
  • Capillary Permeability (drug effects)
  • Ear (pathology)
  • Edema (drug therapy)
  • Female
  • Glucosides (pharmacology)
  • Glycosides (pharmacology)
  • Hypersensitivity, Delayed (drug therapy)
  • Iridoid Glycosides
  • Iridoids
  • Mice
  • Plants, Medicinal
  • Pyrans (pharmacology)
  • Saponins (pharmacology)
  • Serotonin (pharmacology)
  • Terpenes (pharmacology)
  • Tetradecanoylphorbol Acetate (toxicity)
  • Triterpenes

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