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Morphine with dextromethorphan: conversion from other opioid analgesics.

Abstract
MorphiDex, a 1:1 combination of dextromethorphan and morphine, provides satisfactory pain control at a significantly lower morphine daily dose. To determine the appropriate conversion regimens from other oral or transdermal opioid analgesics to MorphiDex (MS:DM), 592 patients with moderate to severe chronic pain requiring daily use of opioid analgesics were enrolled in this multicenter, open-label study. Patients were instructed to use MS:DM as needed to achieve satisfactory pain control. Overall, study patients took a significantly lower morphine daily dose (P = 0.0001), and a higher percentage (P = 0.0001) rated therapy with MS:DM as "very good" or "excellent" compared to their prestudy opioid. The mean daily dose of MS:DM remained level throughout a 10 month study extension period, suggesting that MS:DM may inhibit the development of tolerance to morphine. Most of the adverse events observed with MS:DM were those commonly reported with opioid therapy and were mild to moderate in severity. MS:DM appears safe and effective in treating moderate to severe chronic pain.
AuthorsE Chevlen
JournalJournal of pain and symptom management (J Pain Symptom Manage) Vol. 19 Issue 1 Suppl Pg. S42-9 (Jan 2000) ISSN: 0885-3924 [Print] United States
PMID10687339 (Publication Type: Clinical Trial, Journal Article, Multicenter Study)
Chemical References
  • Analgesics
  • Analgesics, Opioid
  • Drug Combinations
  • Excitatory Amino Acid Antagonists
  • Dextromethorphan
  • Morphine
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Analgesics (administration & dosage, adverse effects, therapeutic use)
  • Analgesics, Opioid (administration & dosage, adverse effects, therapeutic use)
  • Dextromethorphan (administration & dosage, adverse effects, therapeutic use)
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Drug Combinations
  • Excitatory Amino Acid Antagonists (administration & dosage, adverse effects, therapeutic use)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Morphine (administration & dosage, adverse effects, therapeutic use)
  • Retreatment

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