Abstract |
MorphiDex, a 1:1 combination of dextromethorphan and morphine, provides satisfactory pain control at a significantly lower morphine daily dose. To determine the appropriate conversion regimens from other oral or transdermal opioid analgesics to MorphiDex (MS:DM), 592 patients with moderate to severe chronic pain requiring daily use of opioid analgesics were enrolled in this multicenter, open-label study. Patients were instructed to use MS:DM as needed to achieve satisfactory pain control. Overall, study patients took a significantly lower morphine daily dose (P = 0.0001), and a higher percentage (P = 0.0001) rated therapy with MS:DM as "very good" or "excellent" compared to their prestudy opioid. The mean daily dose of MS:DM remained level throughout a 10 month study extension period, suggesting that MS:DM may inhibit the development of tolerance to morphine. Most of the adverse events observed with MS:DM were those commonly reported with opioid therapy and were mild to moderate in severity. MS:DM appears safe and effective in treating moderate to severe chronic pain.
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Authors | E Chevlen |
Journal | Journal of pain and symptom management
(J Pain Symptom Manage)
Vol. 19
Issue 1 Suppl
Pg. S42-9
(Jan 2000)
ISSN: 0885-3924 [Print] United States |
PMID | 10687339
(Publication Type: Clinical Trial, Journal Article, Multicenter Study)
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Chemical References |
- Analgesics
- Analgesics, Opioid
- Drug Combinations
- Excitatory Amino Acid Antagonists
- Dextromethorphan
- Morphine
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Analgesics
(administration & dosage, adverse effects, therapeutic use)
- Analgesics, Opioid
(administration & dosage, adverse effects, therapeutic use)
- Dextromethorphan
(administration & dosage, adverse effects, therapeutic use)
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Drug Combinations
- Excitatory Amino Acid Antagonists
(administration & dosage, adverse effects, therapeutic use)
- Female
- Humans
- Male
- Middle Aged
- Morphine
(administration & dosage, adverse effects, therapeutic use)
- Retreatment
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