A man with natural killer cell lymphoma showing 46,XX and deletion 6q.

Abstract

Specific chromosomal abnormalities have been shown to be associated with certain types of leukemia and lymphoma. We and others have recently demonstrated del(6)(q21q25) as being strongly associated with natural killer cell lymphoma/leukemia. In this report, we describe a case of natural killer cell lymphoma with a clonal chromosomal abnormality of 46,X,-Y,+X,t(2;9)(q31;p24), del(4)(q21q25),del(6)(q21q23), and propose that the region 6q23 is probably an important site of genetic alteration in this group of tumors.

• Authors: K F Wong, J K Chan, P H Yu, C C So
• Journal: Cancer genetics and cytogenetics (Cancer Genet Cytogenet) Vol. 112 Issue 2 Pg. 165-8 (Jul 15 1999) ISSN: 0165-4608 [Print] United States
• PMID: 10686946 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Biopsy
• Chromosome Deletion
• Chromosomes, Human, Pair 6
• Humans
• Karyotyping
• Killer Cells, Natural
• Lymph Nodes (pathology)
• Lymphoma, Non-Hodgkin (genetics, pathology)
• Male