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[Administration of tobramycin aerosols in patients with nosocomial pneumonia: a preliminary study].

AbstractOBJECTIVE:
The aim of this study was to assess renal and respiratory tolerance of aerosolized tobramycin in intubated and mechanically ventilated patients with nosocomial pneumonia.
PATIENTS AND METHODS:
This was a multicenter, randomized, double-blind, placebo controlled study. Thirty-eight mechanically ventilated patients with documented nosocomial pneumonia were included. Patients treated with intravenous betalactam and tobramycin were randomly allocated to receive aerosolized tobramycin (6 mg/kg/day, n = 21) or placebo (n = 17). The aerosol was administered via a pneumatic nebulizer once a day for 5 days.
RESULTS:
Respiratory tolerance was good in all but two patients. No acute renal failure occurred. By day 10, 7 patients in the tobramycin group (35%) had been extubated versus 3 in the placebo group (18.5%, p = 0.18). By day 28, 6 patients had died (2 in the tobramycin group and 4 in the placebo group, p = 0.23).
CONCLUSION:
Aerosolized tobramycin was well tolerated in ventilated patients with documented nosocomial pneumonia.
AuthorsP Le Conte, G Potel, E Clémenti, A Legras, D Villers, E Bironneau, J Cousson, D Baron
JournalPresse meĢdicale (Paris, France : 1983) (Presse Med) Vol. 29 Issue 2 Pg. 76-8 (Jan 22 2000) ISSN: 0755-4982 [Print] FRANCE
Vernacular TitleAdministration d'aérosols de tobramycine chez des patients ayant une pneumopathie nosocomiale: étude préliminaire.
PMID10682031 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References
  • Aerosols
  • Anti-Bacterial Agents
  • Placebos
  • Creatinine
  • Tobramycin
Topics
  • Adult
  • Aerosols
  • Aged
  • Anti-Bacterial Agents (administration & dosage, adverse effects)
  • Creatinine (blood)
  • Cross Infection (drug therapy)
  • Data Interpretation, Statistical
  • Double-Blind Method
  • Drug Tolerance
  • Female
  • Humans
  • Intubation, Intratracheal
  • Kidney (drug effects)
  • Male
  • Middle Aged
  • Placebos
  • Pneumonia, Bacterial (drug therapy)
  • Respiration (drug effects)
  • Respiration, Artificial
  • Time Factors
  • Tobramycin (administration & dosage, adverse effects)
  • Treatment Outcome

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