| Abstract | BACKGROUND: For UVB, the most effective wavelength in clearing psoriatic lesions was found to be of 313 nm. The efficacy of whole body exposure to narrow-band UVB (311 nm) combined with dithranol in psoriasis has not been evaluated to date. OBJECTIVE: Evaluation of the clinical efficacy of phototherapy with narrow-band UVB (311 nm) and dithranol for psoriasis by means of whole body exposures and analysis of the mean cumulative irradiation dose. METHODS: In this open pilot study, 13 patients were treated for 4-5 weeks. Evaluation of the therapeutic efficacy was performed by comparing the Psoriasis Area and Severity Index (PASI) scores at baseline and after 4 weeks of treatment. The cumulative irradiation dose was also calculated. RESULTS: Evaluation of the PASI scores showed a significant overall reduction of psoriatic lesions after 4 weeks of treatment. The cumulative irradiation dose was similar or lower to those found for phototherapy with narrow-band UVB alone. DISCUSSION: In patients with widespread psoriasis, treatment with narrow-band UVB (311 nm) combined with dithranol is safe and effective, allowing reduction of the cumulative irradiation dose. Copyright (R) 2000 S.Karger AG, Basel |
| Authors | P Carrozza, P Häusermann, F O Nestle, G Burg, R Böni
(Affiliation: Department of Dermatology, University Hospital Zurich, Switzerland. carrozza at gmx.net)
|
| Journal | Dermatology (Basel, Switzerland)
(Dermatology)
Vol. 200
Issue 1
Pg. 35-9
( 2000)
ISSN: 1018-8665 SWITZERLAND |
| PMID | 10681611
(Publication Type: Clinical Trial, Journal Article)
|
| Chemical References |
- Anti-Inflammatory Agents
- Anthralin
|
| Topics |
- Administration, Topical
- Adult
- Anthralin
(therapeutic use)
- Anti-Inflammatory Agents
(therapeutic use)
- Combined Modality Therapy
- Dose-Response Relationship, Radiation
- Female
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Pilot Projects
- Psoriasis
(drug therapy, pathology, radiotherapy)
- Radiotherapy Dosage
- Severity of Illness Index
- Skin
(drug effects, pathology, radiation effects)
- Treatment Outcome
- Ultraviolet Therapy
- Whole-Body Irradiation
|
