Influence of the HDL receptor SR-BI on atherosclerosis.

Abstract

The scavenger receptor class B, type I (SR-BI) is an HDL receptor that mediates selective cholesterol uptake from HDL to cells. In rodents, SR-BI has a critical influence on plasma HDL-cholesterol concentration and structure, the delivery of cholesterol to steroidogenic tissues, female fertility, and biliary cholesterol concentration. SR-BI can also serve as a receptor for non-HDL lipoproteins and appears to play an important role in reverse cholesterol transport. Recent studies involving the manipulation of SR-BI expression in mice, either using adenovirus-mediated or transgenic hepatic overexpression or using homologous recombination for complete functional ablation, indicate that the expression of SR-BI protects against atherosclerosis. If SR-BI has a similar activity in humans, it may become an attractive target for therapeutic intervention.

• Authors: M Krieger, K Kozarsky
• Journal: Current opinion in lipidology (Curr Opin Lipidol) Vol. 10 Issue 6 Pg. 491-7 (Dec 1999) ISSN: 0957-9672 [Print] England
• PMID: 10680042 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Review)

Chemical References

• CD36 Antigens
• Carrier Proteins
• Lipoproteins, HDL
• Membrane Proteins
• RNA-Binding Proteins
• Receptors, Immunologic
• Receptors, Lipoprotein
• Receptors, Scavenger
• SCARB1 protein, human
• Scarb1 protein, mouse
• Scavenger Receptors, Class B
• high density lipoprotein receptors
• high density lipoprotein binding protein

Topics

• Animals
• Arteriosclerosis (physiopathology)
• CD36 Antigens (physiology)
• Carrier Proteins
• Female
• Fertility
• Humans
• Lipoproteins, HDL
• Membrane Proteins
• Mice
• Mice, Transgenic
• RNA-Binding Proteins
• Receptors, Immunologic
• Receptors, Lipoprotein (physiology)
• Receptors, Scavenger
• Scavenger Receptors, Class B