Treatment of infant colic with amino acid-based infant formula: a preliminary study.

Abstract

Infant colic, a common disorder of infancy, is characterized by excessive crying and fussing. In this preliminary study we examined whether Neocate, an amino acid-based formula, would be accepted by formula-fed infants with colic, 3-7 wk of age, and whether Neocate would improve their symptoms. Six infants with colic were studied using Barr-type infant behavior diaries for 3-6 d on their current formula and then for 5-17 d on Neocate exclusively. All infants tolerated Neocate well and all improved, usually within 1-2 d. The total time spent crying and fussing was reduced by an average of 45%, representing a decrease of 1.0 to 5.2 h daily. After colic symptoms improved, infants were challenged with oral doses of 75 mg of bovine IgG at a 1 mg/ml concentration in order to assess its potential role in colic. Bovine IgG challenges resulted in increased crying and fussing behavior, suggesting that this protein may be etiologically important.

• Authors: D C Estep, A Kulczycki Jr
• Journal: Acta paediatrica (Oslo, Norway : 1992) (Acta Paediatr) Vol. 89 Issue 1 Pg. 22-7 (Jan 2000) ISSN: 0803-5253 [Print] Norway
• PMID: 10677052 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Amino Acids
• Carbohydrates
• Dietary Fats
• Immunoglobulin G
• Neocate

Topics

• Administration, Oral
• Amino Acids (administration & dosage)
• Animals
• Carbohydrates (administration & dosage)
• Cattle
• Colic (diet therapy, etiology)
• Crying
• Dietary Fats (administration & dosage)
• Food, Formulated
• Humans
• Immunoglobulin G (administration & dosage, immunology)
• Infant
• Infant Behavior
• Infant Food
• Infant, Newborn
• Male
• Milk Hypersensitivity (complications)
• Time Factors