Abstract |
Infant colic, a common disorder of infancy, is characterized by excessive crying and fussing. In this preliminary study we examined whether Neocate, an amino acid-based formula, would be accepted by formula-fed infants with colic, 3-7 wk of age, and whether Neocate would improve their symptoms. Six infants with colic were studied using Barr-type infant behavior diaries for 3-6 d on their current formula and then for 5-17 d on Neocate exclusively. All infants tolerated Neocate well and all improved, usually within 1-2 d. The total time spent crying and fussing was reduced by an average of 45%, representing a decrease of 1.0 to 5.2 h daily. After colic symptoms improved, infants were challenged with oral doses of 75 mg of bovine IgG at a 1 mg/ml concentration in order to assess its potential role in colic. Bovine IgG challenges resulted in increased crying and fussing behavior, suggesting that this protein may be etiologically important.
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Authors | D C Estep, A Kulczycki Jr |
Journal | Acta paediatrica (Oslo, Norway : 1992)
(Acta Paediatr)
Vol. 89
Issue 1
Pg. 22-7
(Jan 2000)
ISSN: 0803-5253 [Print] Norway |
PMID | 10677052
(Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Amino Acids
- Carbohydrates
- Dietary Fats
- Immunoglobulin G
- Neocate
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Topics |
- Administration, Oral
- Amino Acids
(administration & dosage)
- Animals
- Carbohydrates
(administration & dosage)
- Cattle
- Colic
(diet therapy, etiology)
- Crying
- Dietary Fats
(administration & dosage)
- Food, Formulated
- Humans
- Immunoglobulin G
(administration & dosage, immunology)
- Infant
- Infant Behavior
- Infant Food
- Infant, Newborn
- Male
- Milk Hypersensitivity
(complications)
- Time Factors
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