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Heparin and oral anticoagulants in the treatment of brain ischemia.

Abstract
The use of heparin, heparin analogues, and oral anticoagulation in the treatment of brain ischemia remains controversial. We review the mechanism of action of the heparins and warfarin as well as the data regarding their efficacy and complications in patients with ischemic stroke and venous sinus thrombosis. None of these drugs have proven effective for all forms of cerebral ischemia. Further studies examining the efficacy of anticoagulants in different stroke subgroups will be necessary in order to clarify optimal clinical practice.
AuthorsC J Chaves, L R Caplan
JournalJournal of the neurological sciences (J Neurol Sci) Vol. 173 Issue 1 Pg. 3-9 (Feb 01 2000) ISSN: 0022-510X [Print] Netherlands
PMID10675573 (Publication Type: Journal Article, Review)
Chemical References
  • Anticoagulants
  • Warfarin
  • Heparin
Topics
  • Administration, Oral
  • Anticoagulants (administration & dosage, therapeutic use)
  • Heparin (therapeutic use)
  • Humans
  • Hypoxia-Ischemia, Brain (drug therapy)
  • Warfarin (administration & dosage, therapeutic use)

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