HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice.

Abstract
In lipoatrophic diabetes, a lack of fat is associated with insulin resistance and hyperglycemia. This is in striking contrast to the usual association of diabetes with obesity. To understand the underlying mechanisms, we transplanted adipose tissue into A-ZIP/F-1 mice, which have a severe form of lipoatrophic diabetes. Transplantation of wild-type fat reversed the hyperglycemia, dramatically lowered insulin levels, and improved muscle insulin sensitivity, demonstrating that the diabetes in A-ZIP/F-1 mice is caused by the lack of adipose tissue. All aspects of the A-ZIP/F-1 phenotype including hyperphagia, hepatic steatosis, and somatomegaly were either partially or completely reversed. However, the improvement in triglyceride and FFA levels was modest. Donor fat taken from parametrial and subcutaneous sites was equally effective in reversing the phenotype. The beneficial effects of transplantation were dose dependent and required near-physiological amounts of transplanted fat. Transplantation of genetically modified fat into A-ZIP/F-1 mice is a new and powerful technique for studying adipose physiology and the metabolic and endocrine communication between adipose tissue and the rest of the body.
AuthorsO Gavrilova, B Marcus-Samuels, D Graham, J K Kim, G I Shulman, A L Castle, C Vinson, M Eckhaus, M L Reitman
JournalThe Journal of clinical investigation (J Clin Invest) Vol. 105 Issue 3 Pg. 271-8 (Feb 2000) ISSN: 0021-9738 [Print] United States
PMID10675352 (Publication Type: Journal Article)
Chemical References
  • Fatty Acids
  • Triglycerides
Topics
  • Adipose Tissue (transplantation)
  • Animals
  • Diabetes Mellitus, Experimental (blood, physiopathology, surgery)
  • Diabetes Mellitus, Lipoatrophic (blood, physiopathology, surgery)
  • Fatty Acids (blood)
  • Gene Expression Regulation
  • Gene Transfer Techniques
  • Insulin Resistance
  • Mice
  • Triglycerides (blood)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: