Chromogranin A expression in hepatocellular carcinoma in a patient with germline MEN1 gene mutation.

Abstract

Hepatocellular carcinoma (HCC) was found in a patient with multiple endocrine neoplasia type 1 (MEN 1). The intriguing finding was that the HCC in the patient was positively stained for chromogranin A (CgA), a cellular marker for endocrine and neuroendocrine tumors. The patient had a pancreas endocrine tumor and type C hepatitis, that made pathological diagnosis of the origin of the tumor complicated.

• Authors: K Nakajima, A Sakurai, M Katai, H Yajima, J Mori, M Katakura, S Tsuchiya, K Hashizume
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 39 Issue 1 Pg. 20-4 (Jan 2000) ISSN: 0918-2918 [Print] Japan
• PMID: 10674843 (Publication Type: Case Reports, Journal Article)

Chemical References

• CHGA protein, human
• Chromogranin A
• Chromogranins

Topics

• Carcinoma, Hepatocellular (chemistry, complications)
• Chromogranin A
• Chromogranins (analysis)
• Fatal Outcome
• Germ-Line Mutation
• Glucagonoma (chemistry)
• Hepatitis C (complications)
• Humans
• Liver (chemistry)
• Liver Neoplasms (chemistry, complications)
• Male
• Middle Aged
• Multiple Endocrine Neoplasia Type 1 (complications, genetics)
• Neoplasms, Multiple Primary (chemistry)
• Pancreas (chemistry)
• Pancreatic Neoplasms (chemistry)