HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Antimicrobial resistance in Burkholderia pseudomallei.

Abstract
Four strains of Burkholderia pseudomallei were used to determine the minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and time-kill curves with 13 single antimicrobial agents: ceftazidime, piperacillin, imipenem, amoxicillin/clavulanic acid, doxycycline, cotrimoxazole, kanamycin, rifampicin, ciprofloxacin, trovafloxacin, clarithromycin, azithromycin and meropenem. The time-kill studies were also performed with 33 pairs of combinations of the above antimicrobial agents: 15 combinations which would be expected to be used for acute therapy and 18 combinations for maintenance therapy. The results show that the single and combination antimicrobial agents with bactericidal effects against the four strains of B. pseudomallei which should be used for clinical trials in acute melioidosis are: imipenem, meropenem, and imipenem + azithromycin. The combination antimicrobial agents which should be further studied for the ability to eliminate biofilm and intracellular killing effect are ciprofloxacin + clarithromycin, ciprofloxacin + azithromycin, and imipenem + azithromycin.
AuthorsM Vorachit, P Chongtrakool, S Arkomsean, S Boonsong
JournalActa tropica (Acta Trop) Vol. 74 Issue 2-3 Pg. 139-44 (Feb 5 2000) ISSN: 0001-706X [Print] NETHERLANDS
PMID10674642 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Bacterial Agents
  • Cephalosporins
  • Fluoroquinolones
  • Penicillins
  • Thienamycins
Topics
  • Anti-Bacterial Agents (pharmacology)
  • Biofilms (drug effects)
  • Burkholderia pseudomallei (drug effects)
  • Cephalosporins (pharmacology)
  • Drug Resistance, Microbial
  • Fluoroquinolones
  • Glycocalyx (drug effects)
  • Microbial Sensitivity Tests
  • Penicillins (pharmacology)
  • Thienamycins (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: