Epstein-Barr virus-associated lymphoproliferative disease after a cord blood transplant for Diamond-Blackfan anemia.

Abstract

A 7-year-old boy with Diamond-Blackfan anemia (DBA) developed lymphoproliferative disease (LPD) after a cord blood transplant (CBT). 3.1 x 107/kg mononuclear cells from an HLA one-locus mismatched CB were transplanted after conditioning with total body irradiation (8 Gy), cyclophosphamide (200 mg/kg) and antithymocyte globulin (10 mg/kg). Complete engraftment occurred on day 33 post transplant. Despite the resolution of grade II graft-versus-host disease (GVHD), he died of lymphoma on day 130 post transplant. The tumor was of donor origin, indicating clonal proliferation of Epstein-Barr virus (EBV)-infected B cells. This is the first report of EBV-LPD after CBT. Post-transplant LPD can be a serious EBV-associated complication of CB grafts. Bone Marrow Transplantation (2000) 25, 209-212.

• Authors: S Ohga, Y Kanaya, H Maki, H Takada, K Ohshima, M Kanda, A Nomura, A Suminoe, A Matsuzaki, T Hara
• Journal: Bone marrow transplantation (Bone Marrow Transplant) Vol. 25 Issue 2 Pg. 209-12 (Jan 2000) ISSN: 0268-3369 [Print] England
• PMID: 10673683 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Blood Component Transfusion (adverse effects)
• Child
• Epstein-Barr Virus Infections (blood, etiology, transmission, virology)
• Fanconi Anemia (blood, complications, therapy, virology)
• Fatal Outcome
• Female
• Fetal Blood (cytology, immunology, virology)
• Fetal Tissue Transplantation (adverse effects, immunology)
• Graft Survival
• Graft vs Host Disease (etiology, immunology)
• Hematopoietic Stem Cell Transplantation (adverse effects)
• Herpesvirus 4, Human (physiology)
• Histocompatibility Testing
• Humans
• Lymphoma, B-Cell (blood, etiology, virology)
• Male
• Transplantation Conditioning (adverse effects)