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Chloroxylenol and zinc oxide containing cream (Nels cream) vs. 5% benzoyl peroxide cream in the treatment of acne vulgaris. A double-blind, randomized, controlled trial.

Abstract
Forty-one subjects completed a double-blind controlled randomized study comparing the following: (i) Nels cream (containing chloroxylenol and zinc oxide); (ii) 5% benzoyl peroxide cream; and (iii) the vehicle of the Nels cream. Patients applied the medications twice daily for 8 weeks. At the end of the test period there was no significant difference in the reduction of inflammatory and noninflammatory lesion counts achieved by Nels cream and benzoyl peroxide. Both creams proved superior to the vehicle. Efficacy grading by subjects and investigators showed no significant difference between Nels cream and benzoyl peroxide. However, side-effects such as peeling and dryness caused by the treatment were significantly less in the Nels cream group.
AuthorsP P Papageorgiou, A C Chu
JournalClinical and experimental dermatology (Clin Exp Dermatol) Vol. 25 Issue 1 Pg. 16-20 (Jan 2000) ISSN: 0307-6938 [Print] England
PMID10671963 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Anti-Infective Agents, Local
  • Ointments
  • Xylenes
  • chloroxylenol
  • Zinc Oxide
  • Benzoyl Peroxide
Topics
  • Acne Vulgaris (drug therapy)
  • Adolescent
  • Adult
  • Anti-Infective Agents, Local (administration & dosage)
  • Benzoyl Peroxide (administration & dosage)
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Middle Aged
  • Ointments
  • Xylenes (administration & dosage)
  • Zinc Oxide (administration & dosage)

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